NFL Week 1 Predictions & Preview – Picking 5 Big Games

Colts – Bills


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One of the more interesting match-ups on the Week 1 docket involves the Indianapolis Colts travelling to Buffalo to play a Bills team that has been rejuvenated by the hiring of former Jets head coach Rex Ryan and the addition of a few big names via trades and free agency.

But the Colts are expected to be a Super Bowl contender, and their fleet of impressive receivers grew in the off-season. They added longtime Texan Andre Johnson, although longtime Colt Reggie Wayne is no longer in the fold. Andrew Luck should be good for at least three passing touchdowns in this one, and I think it gets out of hand down the stretch.

Prediction: Colts 32 Bills 17

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